Invention Grant
- Patent Title: Condensed ring compounds having dopamine D3 receptor antagonistic effect
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Application No.: US16964305Application Date: 2019-01-25
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Publication No.: US11578084B2Publication Date: 2023-02-14
- Inventor: Hiroyuki Tobinaga , Koji Masuda
- Applicant: Shionogi & Co., Ltd.
- Applicant Address: JP Osaka
- Assignee: Shionogi & Co., Ltd.
- Current Assignee: Shionogi & Co., Ltd.
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JPJP2018-011086 20180126,JPJP2018-219158 20181122
- International Application: PCT/JP2019/002396 WO 20190125
- International Announcement: WO2019/146739 WO 20190801
- Main IPC: C07D513/04
- IPC: C07D513/04 ; C07D471/04 ; C07D519/00 ; A61P25/00
Abstract:
Novel compounds having a D3 receptor antagonistic effect are provided.
The compound represented by Formula (IA)′: wherein A is S or O; R1a is substituted or unsubstituted alkyloxy or the like, R2a to R2d are each independently hydrogen atoms or the like, ring B is a 4- to 8-membered non-aromatic carbocycle or the like, R3 is each independently halogen or the like, r is an integer of 0 to 4, R4 is substituted or unsubstituted aromatic heterocyclyl or the like, or a pharmaceutically acceptable salt thereof.
The compound represented by Formula (IA)′: wherein A is S or O; R1a is substituted or unsubstituted alkyloxy or the like, R2a to R2d are each independently hydrogen atoms or the like, ring B is a 4- to 8-membered non-aromatic carbocycle or the like, R3 is each independently halogen or the like, r is an integer of 0 to 4, R4 is substituted or unsubstituted aromatic heterocyclyl or the like, or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20210040117A1 CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT Public/Granted day:2021-02-11
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