Invention Grant
- Patent Title: Device for the cultivation of and radiation-induced killing of cells and method for analyzing a migration and/or healing of a wound
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Application No.: US16762462Application Date: 2018-11-06
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Publication No.: US11578298B2Publication Date: 2023-02-14
- Inventor: Joachim Wegener , Carina Schmittlein , Michael Skiba
- Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V. , UNIVERSITÄT REGENSBURG
- Applicant Address: DE Munich; DE Regensburg
- Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V.,UNIVERSITÄT REGENSBURG
- Current Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V.,UNIVERSITÄT REGENSBURG
- Current Assignee Address: DE Munich; DE Regensburg
- Agency: Leydig, Voit & Mayer, Ltd.
- Priority: DE102017220067.7 20171110
- International Application: PCT/EP2018/080229 WO 20181106
- International Announcement: WO2019/091939 WO 20190516
- Main IPC: C12M1/42
- IPC: C12M1/42 ; C12M1/12 ; C12M1/34 ; C12M1/36 ; G01N33/50

Abstract:
The invention relates to a device designed for the cultivation and radiation-induced killing of living biological cells. The device comprises a flat substrate and a functional layer for creating a wound in biological cells, said functional layer being applied to the flat substrate. The functional layer contains at least one photosensitizer which is designed to convert triplet oxygen into singlet oxygen by the application of electromagnetic radiation. As a result, biological cells on the functional layer can be killed by irradiation of low-intensity electromagnetic radiation. A wound can be introduced into a cell layer at a locally defined point easily, quickly, carefully, and in a flexible and cost-effective manner and thus the healing of the wound can be studied. The invention further relates to uses of the devices and a method for analyzing a migration and/or wound healing behavior of biological cells.
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