A system and method of detecting defects in an analog circuit is provided. A method includes identifying a channel connected block (CCB) from a netlist, creating defect for the CCB to be injected during a simulation, obtaining a first measurement of an output node of the CCB by performing a first analog circuit simulation for the CCB based on providing excitations as inputs to the CCB and obtaining a second measurement of the output node of the CCB by performing a second analog circuit simulation for the CCB based on providing the excitations as the inputs to the CCB and injecting the defect. The method can further include determining a defect type based on the first measurement and the second measurement.