Invention Grant
- Patent Title: Process for producing a Tan IIA nanoliposome system for foods and medical products
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Application No.: US17127144Application Date: 2020-12-18
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Publication No.: US11583498B2Publication Date: 2023-02-21
- Inventor: Hong Ngoc Thi Dang , Nam Hai Lai
- Applicant: Wakamono Corporation
- Applicant Address: VN Ho Chi Minh
- Assignee: Wakamono Corporation
- Current Assignee: Wakamono Corporation
- Current Assignee Address: VN Ho Chi Minh
- Agency: Fulwider Patton LLP
- Priority: VN1-2020-00059 20200103
- Main IPC: A23L33/105
- IPC: A23L33/105 ; B82Y5/00 ; A61K9/127 ; A61K36/537

Abstract:
The invention relates to a process for producing a Tan IIA nanoliposome system for foods and medical products, comprises: (i) preparing a dispersed phase by dissolving Tan IIA in ethanol in a Tan IIA weight:ethanol volume ratio of 8:10 by a stirrer at 300-500 rpm with heating to 40-60° C. within 4-8 hours; (ii) preparing a liposome carrier consisting of lecithin and olive oil in a ratio of 1:3 by weight by mixing in a constant temperature bath at 40-60° C. to ensure that lecithin is completely dissolved in the oil while stirring; (iii) adding the carrier to the dispersed phase in a ratio of 40:60 by weight, further heating the carrier and dispersed phase mixture to 40-60° C. and stirring at 800-1000 rpm within 1 to 2 hours; (iv) cooling the resulting mixture to 25° C. and pumping the cooled mixture, using an ultrasonic atomizer nozzle at 60 Hz (10-20 μm droplet size, 10 mL/min), into 1-1.5 L of distilled water (with the temperature of the distilled water at 25° C.) to obtain a liposome suspension-water mixture; (v) homogenizing the liposome suspension-water mixture by pumping through a high pressure homogenizer at 30 Mpa to obtain a Tan IIA nanoliposome system as a homogeneous and stable mixture with a confirmed particle size smaller than 200 nm.
Public/Granted literature
- US20210205220A1 PROCESS FOR PRODUCING A TAN IIA NANOLIPOSOME SYSTEM FOR FOODS AND MEDICAL PRODUCTS Public/Granted day:2021-07-08
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