Systems and methods to improve ride comfort for users within a vehicle during operation of the vehicle are disclosed. Exemplary implementations may: generate output signals; determine the current operational information regarding the vehicle; determine a current set of forces operating on one or more of the vehicle and one or more of the users within the vehicle; compare a characteristic of the current set of forces to a comfort threshold level; and responsive to the characteristic breaching the comfort threshold level, effectuate a modification in the operation of the vehicle such that a subsequent change in the characteristic that corresponds to the modification reduces and/or remedies the breach of the comfort threshold level.