Invention Grant
- Patent Title: 2-thioxothiazolidin-4-one derivatives active as transthyretin ligands and uses thereof
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Application No.: US17405506Application Date: 2021-08-18
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Publication No.: US11584727B2Publication Date: 2023-02-21
- Inventor: Rui Manuel Pontes Meireles Ferreira de Brito , Carlos José Vieira Simões , Teresa Margarida Vasconcelos Dias de Pinho e Melo , Bruno Lourenço da Silva Victor , Zaida Catarina Lourenço de Almeida , Ana Lúcia Cabral Cardoso Lopes , Bruno Filipe Oliveira Nascimento
- Applicant: BSIM Therapeutics, S.A.
- Applicant Address: PT Coimbra
- Assignee: BSIM Therapeutics, S.A.
- Current Assignee: BSIM Therapeutics, S.A.
- Current Assignee Address: PT Coimbra
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07D277/36
- IPC: C07D277/36 ; C07D277/34 ; A61K9/00 ; A61K31/426 ; A61K45/06
Abstract:
Compounds are provided for stabilizing protein transthyretin (TTR) and inhibiting amyloid fibril formation, for example, transthyretin-mediated amyloid fibril formation, and for treating, preventing, or ameliorating one or more symptoms of amyloid diseases, for example, transthyretin-related amyloidosis (ATTR).
Public/Granted literature
- US20220267286A2 2-THIOXOTHIAZOLIDIN-4-ONE DERIVATIVES ACTIVE AS TRANSTHYRETIN LIGANDS AND USES THEREOF Public/Granted day:2022-08-25
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