Invention Grant
- Patent Title: Compositions and methods for identification, assessment, prevention, and treatment of melanoma using PD-L1 isoforms
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Application No.: US16365978Application Date: 2019-03-27
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Publication No.: US11584788B2Publication Date: 2023-02-21
- Inventor: F. Stephen Hodi , Jun Zhou , Gordon J. Freeman , Jingjing Li , Xinqi Wu
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Foley Hoag LLP
- Agent DeAnn F. Smith; Philip S. Choi
- Main IPC: C07K16/00
- IPC: C07K16/00 ; C07K14/705 ; C07K16/28 ; C07K16/30 ; G01N33/50 ; G01N33/574 ; A61K9/00 ; A61K38/17 ; A61K39/395 ; A61K45/06 ; C12Q1/6886 ; A61K38/00 ; A61K39/00
Abstract:
The present invention relates to compositions and methods for identifying, assessing, preventing, and treating melanoma. A variety of PD-L1 isoform biomarkers are provided, wherein alterations in the copy number of one or more of the biomarkers and/or alterations in the amount, structure, and/or activity of one or more of the biomarkers is associated with melanoma status.
Information query
