A biosensor for the rapid, inexpensive, quantitative, and convenient detection of SARS-CoV-2 biomarkers, methods of manufacturing, and methods of using the same, to identify a patient's prognosis and past/present SARS-CoV-2 infection status, wherein the biosensor comprises a microfluidics layer, a multimodal sensing layer comprising two or more working electrodes, and a logic circuit that may include a processor and non-transitory memory with computer executable instructions embedded thereon.