The invention involves a device and method for acquiring bone marrow aspirate. The system includes an elongated cannulated fastener having a threaded end for attachment to a bone. The threaded portion includes a directional aperture sized to allow marrow to be drawn into the cannula. The directional aperture also allows the user to direct the aperture in a desired direction within the bone for acquisition of the marrow. The distal end of the cannulated fastener includes a connector which may be in the form of a Luer lock to allow vacuum to be applied to the cannula for drawing the marrow into a syringe or the like.