Methods and apparatus to align applique cutters are disclosed. A disclosed example alignment rail is for use with cutting an applique relative to a surface of a vehicle. The example alignment rail includes a base to contact the surface. The example alignment rail also includes a body including a cross-sectional profile extending along a longitudinal axis of the alignment rail. The example alignment rail also includes a groove of the cross-sectional profile extending along the longitudinal axis, where the groove is to align movement of a cutting tool to cut the applique.