Invention Grant
- Patent Title: Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
-
Application No.: US16984936Application Date: 2020-08-04
-
Publication No.: US11591324B2Publication Date: 2023-02-28
- Inventor: Ana Maria Cuervo , Evripidis Gavathiotis , Qisheng Xin , Bhaskar C. Das
- Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE
- Applicant Address: US NY Bronx
- Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
- Current Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
- Current Assignee Address: US NY Bronx
- Agency: Cantor Colburn LLP
- Main IPC: C07D413/10
- IPC: C07D413/10 ; C07D265/36 ; C07C279/22
Abstract:
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in subjects in need thereof.
Public/Granted literature
- US20210053958A1 RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTOPHAGY MODULATORS AND USES THEREOF Public/Granted day:2021-02-25
Information query
