![Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide, and methods of production](/docs/US/2023-02-28/US11591345B2/abs.jpg.600x600.jpg)
- Patent Title: Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide, and methods of production
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Application No.: US16875545Application Date: 2020-05-15
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Publication No.: US11591345B2Publication Date: 2023-02-28
- Inventor: Paroma Chakravarty , Chong Han , Sean M. Kelly , Karthik Nagapudi , Scott Savage
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Zong-Qiang Bill Tian
- Main IPC: C07D498/04
- IPC: C07D498/04 ; A61P35/00 ; A61P35/02 ; A61P35/04 ; A61K9/20
![Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide, and methods of production](/abs-image/US/2023/02/28/US11591345B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to crystalline polymorph forms of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide (GDC-0077), having the structure, Formula I: or stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, and processes of preparing the polymorph forms.
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