Invention Grant
- Patent Title: Orthogonal protecting groups for the preparation of stereodefined phosphorothioate oligonucleotides
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Application No.: US16497952Application Date: 2018-03-20
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Publication No.: US11591362B2Publication Date: 2023-02-28
- Inventor: Konrad Bleicher , Dennis Jul Hansen , Erik Daa Funder
- Applicant: Roche Innovation Center Copenhagen A/S
- Applicant Address: DK Hørsholm
- Assignee: Roche Innovation Center Copenhagen A/S
- Current Assignee: Roche Innovation Center Copenhagen A/S
- Current Assignee Address: DK Hørsholm
- Agency: Smith Gambrell & Russell LLP
- Agent Judy Jarecki-Black; Ram W. Sabnis
- Priority: EP17163506 20170329
- International Application: PCT/EP2018/057069 WO 20180320
- International Announcement: WO2018/177825 WO 20181004
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H1/00 ; C07H19/10
Abstract:
The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers comprising an amine containing chiral auxiliary group, and methods of orthogonally protecting the nitrogen of chiral auxiliaries during oligonucleotide synthesis, preventing post elongation chain cleavage, increasing yield and purity of stereodefined phosphorothioate oligonucleotides.
Public/Granted literature
- US20210179658A1 ORTHOGONAL PROTECTING GROUPS FOR THE PREPARATION OF STEREODEFINED PHOSPHOROTHIOATE OLIGONUCLEOTIDES Public/Granted day:2021-06-17
Information query
