Invention Grant
- Patent Title: Recombinant human/bovine parainfluenza virus 1 (HPIV1) expressing a chimeric RSV/HPIV1 F protein and uses thereof
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Application No.: US16877319Application Date: 2020-05-18
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Publication No.: US11591372B2Publication Date: 2023-02-28
- Inventor: Peter Collins , Bo Liang , Shirin Munir , Anne Schaap Nutt , Ursula Buchholz , Natalie Mackow , Peter Kwong , Barney Graham , Jason McLellan
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Klarquist Sparkman, LLP
- Main IPC: C07K14/005
- IPC: C07K14/005 ; A61K39/12 ; A61P31/14 ; A61K39/155 ; A61K39/00
Abstract:
Recombinant paramyxoviruses including a viral genome encoding a heterologous gene are provided. In several embodiments, the recombinant paramyxovirus is a recombinant parainfluenza virus, such as a recombinant PIV3 including a viral genome encoding a heterologous respiratory syncytial virus F ectodomain linked to the transmembrane domain and the cytoplasmic tail of the F protein from the PIV3. Nucleic acid molecules including the genome of a recombinant paramyxoviruses are also provided. The recombinant viruses may advantageously be used in vaccine formulations, such as for vaccines against parainfluenza virus and respiratory syncytial virus.
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