Invention Grant
- Patent Title: Methods and compositions for the generation and use of humanized conformation-specific phosphorylated tau antibodies
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Application No.: US16762141Application Date: 2018-11-08
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Publication No.: US11591385B2Publication Date: 2023-02-28
- Inventor: Shankar Kumar , Naoya Tsurushita , Michael Ahlijanian , Martin Jefson
- Applicant: Pinteon Therapeutics Inc.
- Applicant Address: US MA Newton Centre
- Assignee: Pinteon Therapeutics Inc.
- Current Assignee: Pinteon Therapeutics Inc.
- Current Assignee Address: US MA Newton Centre
- Agency: Foley & Lardner LLP
- International Application: PCT/US2018/059833 WO 20181108
- International Announcement: WO2019/094595 WO 20190516
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61P25/28 ; G01N33/533 ; A61K39/00
Abstract:
The present disclosure relates generally to conformation-specific antibodies that can bind to and neutralize the activity of phosphorylated-Threonine 231-tau protein (pT231-tau). The antibodies of the present technology are useful in methods for treating a neurological disorder associated with elevated cis-pT231-tau protein expression in a subject in need thereof.
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