Invention Grant
- Patent Title: Human methylthioadenosine/adenosine depleting enzyme variants for cancer therapy
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Application No.: US17516639Application Date: 2021-11-01
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Publication No.: US11591579B2Publication Date: 2023-02-28
- Inventor: Everett Stone
- Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US TX Austin
- Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee Address: US TX Austin
- Agency: Parker Highlander PLLC
- Main IPC: C12N9/10
- IPC: C12N9/10 ; A61K47/60 ; C07K16/28 ; A61P35/00 ; A61K38/45 ; A61K45/06
Abstract:
Disclosed herein are compositions related to conjugated polypeptides with MTA/ADO-degrading enzyme activity. The conjugated polypeptides are engineered to allow for maximal conjugation while maintaining catalytic activities. Also disclosed are nucleic acids, expression vectors, and host cells related to the conjugated polypeptides. Further disclosed are methods of using the pharmaceutical formulations comprising above to treat cancer.
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