Invention Grant
- Patent Title: Force-controlled nanoswitch assays for single-molecule detection in complex biological fluids
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Application No.: US16765375Application Date: 2018-11-20
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Publication No.: US11591636B2Publication Date: 2023-02-28
- Inventor: Wesley Philip Wong , Johanna Blass , Darren Yang , Clinton H. Hansen
- Applicant: Children's Medical Center Corporation
- Applicant Address: US MA Boston
- Assignee: Children's Medical Center Corporation
- Current Assignee: Children's Medical Center Corporation
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2018/062141 WO 20181120
- International Announcement: WO2019/100080 WO 20190523
- Main IPC: C12Q1/6804
- IPC: C12Q1/6804
Abstract:
Provided herein are methods and products for detecting analytes in a sample. The analytes may be rare analytes such as biomarkers in a biological sample. These methods make use of nucleic acid nanoswitches that adopt a particular conformation and have a particular length in the presence of an analyte.
Public/Granted literature
- US20200340033A1 FORCE-CONTROLLED NANOSWITCH ASSAYS FOR SINGLE-MOLECULE DETECTION IN COMPLEX BIOLOGICAL FLUIDS Public/Granted day:2020-10-29
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