A multi-key lock core includes a housing, a driving cylinder, a plurality of circular lock plates, and a lock rod. The driving cylinder is disposed in the housing, a sidewall of the driving cylinder is provided with a penetration portion, and the driving cylinder is rotatable to the penetration portion to correspond to an engagement recessed portion. The circular lock plates are disposed in the driving cylinder and each include an outer edge provided with a first recessed portion, and the outer edge of at least one of the circular lock plates is further provided with a second recessed portion. The lock rod is disposed in the penetration portion, and may partially enter the engagement recessed portion to restrict rotation of the driving cylinder. A first key may push the circular lock plates to rotate to the first recessed portion to correspond to the penetration portion, so that the lock rod can move to partially enter the first recessed portion and detach from the engagement recessed portion. The second key may push the circular lock plates to rotate to the second recessed portion and the first recessed portion to correspond to the penetration portion, so that the lock rod can move to partially enter the second recessed portion and the first recessed portion and detach from the engagement recessed portion.