A lock includes a base and movable element connected to a handle operable by a user and movable between a first position corresponding to an open condition of the handle and a second position corresponding to a closed condition. An operating element is rotatably mounted on the base and connected to a device for releasing a closing panel, and is rotatable between a first position corresponding to an open condition of the panel and a second position corresponding to a closed condition. A transmission acts between the movable an operating elements and kinematically connects the movable and operating elements such that movement of the movable element causes rotation of the operating element. An uncoupling device acts on the transmission for disengaging kinematically, and in a controlled way, the movable element from the operating element to disable actuation of the operating element by the movable element.