A dehumidifying air handling unit for an HVACR system includes a housing, a desiccant wheel, and a cooling heat exchanger. A main airflow path extending through the housing from an air inlet to and air discharged outlet of the housing. The desiccant wheel includes a first end and a second end that are each disposed in the main airflow path and a metal organic framework desiccant that is moved between the first end and the second end. A desiccant wheel includes a metal organic framework desiccant disposed on a surface of the desiccant wheel. Rotation of the desiccant wheel moves a position of the surface between a first end and a second end of the desiccant wheel. The metal organic framework desiccant has an majority absorption-desorption operating band of 25% relative humidity or less.