A cryostat chuck is disclosed. The disclosed chuck may be configured for use in a frozen-sectioning device, such as a cryostat, or other suitable host equipment. The disclosed chuck may include a tab portion configured, in accordance with some embodiments, to provide a means for gripping the chuck by hand (e.g., human or robotic) or by a tool or other desired interfacing element. The tab portion may serve to distance a user's hand or piece of gripping equipment from the sharp microtome of the host cryostat, reducing the opportunity of sustaining bodily injury or equipment damage. Moreover, the tab portion may provide a means by which the cryostat chuck may be manipulated when inserting, adjusting, or removing the chuck prior to, during, or after engagement by the cryostat (or other suitable host equipment).