An information handling system may include at least one processor; and a non-transitory memory coupled to the at least one processor. The information handling system may be configured to: execute a plurality of virtual machines having workloads associated therewith; during selected times, apply a plurality of configuration settings relating to the at least one processor while executing the workloads of the plurality of virtual machines; track a plurality of performance metrics relating to the at least one processor during the selected times; and predictively determine a selected one of the plurality of configuration settings that is predicted to improve performance of the workloads.