Operating system deactivation of write protection for a storage block is provided absent quiescing of processors in a multi-processor computing environment. The process includes receiving an address translation protection exception interrupt resulting from an attempted write access by a processor to a storage block, and determining by the operating system whether write protection for the storage block is active. Based on write protection for the storage block not being active, the operating system issues an instruction to clear or modify translation lookaside buffer entries of the processor associated with the storage block, absent waiting for an action by another processor of multiple processors of the computing environment, to facilitate write access to the storage block proceeding at the processor.