A system for determining a plurality of nutritional needs of a user and generating a nutrient supplementation plan using artificial intelligence includes at least a computing device designed and configured to receive, from a user, at least a biological extraction, generate, using the at least a biological extraction and a first machine-learning process, a plurality of nutritional needs of the user, determine a nutritional input to the user, detect at least a nutrition deficiency as a function of the plurality of nutritional needs and the nutritional input, and calculate at least a supplement dose from the plurality of nutritional needs and at the least a nutrition deficiency.