Apparatuses, systems, and methods for a wireless device to disable a HARQ feedback in either a semi-static way or in a dynamic way and to perform HARQ optimization. The wireless device may be configured to receive a first set and a second set of HARQ process numbers, where the first set and the second set of HARQ process numbers correspond to a first set and a second set of HARQ processes respectively, where each HARQ process in the first set of HARQ processes is configured to enable a HARQ feedback, and where each HARQ process in the second set of HARQ processes is configured to disable or enable a HARQ feedback. The wireless device may be configured to receive a grant configuration or a SPS, where the grant configuration or the SPS include a flag indicating whether a HARQ-based retransmission is disabled.