Invention Grant
- Patent Title: Tailored combinatorial epigenetic therapies for P53 gain-of-function tumors
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Application No.: US15110967Application Date: 2015-01-14
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Publication No.: US11596636B2Publication Date: 2023-03-07
- Inventor: Shelley L. Berger , Xianxin Hua , Morgan Sammons , Jiajun Zhu
- Applicant: The Trustees of the University of Pennsylvania
- Applicant Address: US PA Philadelphia
- Assignee: The Trustees of the University of Pennsylvania
- Current Assignee: The Trustees of the University of Pennsylvania
- Current Assignee Address: US PA Philadelphia
- Agency: Riverside Law LLP
- International Application: PCT/US2015/011355 WO 20150114
- International Announcement: WO2015/108940 WO 20150723
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/136 ; A61K31/519 ; A61K31/713
Abstract:
The present invention provides compositions and methods for treating and preventing cancer. The invention comprises an inhibitor of epigenetic regulators, including MLL1, MLL2, MOZ, menin, WDR5, or a combination thereof. In one embodiment, the invention provides a personalized method of treating a cancer as dependent upon its epigenetic signature.
Public/Granted literature
- US20160339035A1 Tailored Combinatorial Epigenetic Therapies for P53 Gain-of-Function Tumors Public/Granted day:2016-11-24
Information query
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