- Patent Title: CHK1 (SRA737)/PARPi combination methods of inhibiting tumor growth
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Application No.: US16604116Application Date: 2018-04-10
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Publication No.: US11596637B2Publication Date: 2023-03-07
- Inventor: Christian Andrew Hassig , Bryan William Strouse , Ryan James Hansen , Kenna Lynn Anderes
- Applicant: SIERRA ONCOLOGY, INC.
- Applicant Address: US MI Plymouth
- Assignee: SIERRA ONCOLOGY, INC.
- Current Assignee: SIERRA ONCOLOGY, INC.
- Current Assignee Address: US MI Plymouth
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2018/026917 WO 20180410
- International Announcement: WO2018/191277 WO 20181018
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61P35/00 ; A61K31/166 ; A61K31/4184 ; A61K31/4535 ; A61K31/454 ; A61K31/4709 ; A61K31/496 ; A61K31/497 ; A61K31/501 ; A61K31/502 ; A61K31/5025 ; A61K31/519 ; A61K31/55 ; A61K31/551
Abstract:
Herein disclosed are combinations of Checkpoint Kinase 1 (Chk1) inhibitors and PARP inhibitors useful for inhibiting the growth of tumors such as those in patients with cancer. In particular, the combination demonstrates remarkable synergistic effects on cancer cells that are representative models for tumors. Also provided for are methods for treating disorders or diseases mediated or affected by Chk1 and/or PARP activity.
Public/Granted literature
- US20210077499A1 CHK1 (SRA737)/PARPI COMBINATION METHODS OF INHIBITING TUMOR GROWTH Public/Granted day:2021-03-18
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