Invention Grant
- Patent Title: Substituted indole Mcl-1 inhibitors
-
Application No.: US16081709Application Date: 2017-03-03
-
Publication No.: US11596639B2Publication Date: 2023-03-07
- Inventor: Taekyu Lee , James C. Tarr , KyuOk Jeon , James M. Salovich , Subrata Shaw , Nagarathanam Veerasamy , Kwangho Kim , Plamen P. Christov , Edward T. Olejniczak , Bin Zhao , Stephen W. Fesik , Zhiguo Bian
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/US2017/020699 WO 20170303
- International Announcement: WO2017/152076 WO 20170908
- Main IPC: A61P35/00
- IPC: A61P35/00 ; A61K45/06 ; C07D487/04 ; A61K31/551 ; A61K31/4985 ; A61K31/506 ; A61K31/5377 ; A61K31/538 ; C07D401/14 ; C07D403/04 ; C07D403/14 ; C07D519/00
Abstract:
The present disclosure provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present disclosure also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
Public/Granted literature
- US20210283138A1 SUBSTITUTED INDOLE MCL-1 INHIBITORS Public/Granted day:2021-09-16
Information query
IPC分类:
| A | 人类生活必需 |
| A61 | 医学或兽医学；卫生学 |
| A61P | 化合物或药物制剂的特定治疗活性 |
| A61P35/00 | 抗肿瘤药 |
