The invention belongs to the technical field of composite membrane, and in particular discloses a UIO-66-NH2 doped organosilicon high salinity wastewater treatment membrane and a preparation method thereof. The membrane is formed into UIO-66-NH2/organosilicon hybrid membrane on the prefabricated ceramic support surface through the dip-coating method by doping the UIO-66-NH2 metal-organic framework material into the organosilicon polymeric sol. The UIO-66-NH2/organosilicon hybrid membrane prepared by the present invention exhibits high water permeability (up to 1.6×10−10 m3/(m2 s Pa) and high salt retention (NaCl retention rate is more than 99.9. %) in the application of pervaporation desalination, and maintains stable membrane structure in the treatment process of TDS>5 wt % high salinity wastewater.