A system for spraying plants comprises a location-determining receiver for estimating a position of a sprayer with respect to one or more rows of plants. A distance sensor is arranged to measure a distance between a nozzle assembly and a plant row segment. A guidance module is adapted to align the nozzle assembly with a target path between the rows of plants, such as a centered path between the rows, or offset between the rows of the plants. A first nozzle is targeted toward a first zone with respect to the plant row segment based on a first spray pattern of the first nozzle. A second nozzle is targeted toward a second zone with respect to the plant row segment based on a second spray pattern of the second nozzle. A nozzle selection module for selecting automatically a first nozzle or a second nozzle based on maximum coverage of a target zone around the plant segment based on the first zone, the second zone, and the measured distance.