A NMQL grinding device of ultrasonic vibration assists grinding fluid micro-channel infiltration, and solves the problem that nanofluids are difficult to fully infiltrate the grinding zone in the prior art. Fully considers the impact of thickness of undeformed grinding debris on the grinding process and the lubrication state of single grains during material removal in the grinding process, the advantage of ultrasonic vibration assistance on improving the lubri-cooling performance of NMQL grinding is effectively achieved. According to the solution, the device includes an ultrasonic vibration mechanism capable of adjusting the spatial position of ultrasonic vibrators, the mechanism being arranged on a worktable; a NMQL grinding mechanism, arranged above a workpiece fixing table; and a grinding force measuring mechanism, including a dynamometer and a grinding force controller connected with the dynamometer, the dynamometer being arranged at the bottom of the ultrasonic vibration mechanism.