Example methods, apparatus, systems, and articles of manufacture (e.g., physical storage media) to facilitate application and portability of activity profiles and vehicle cabin configuration are disclosed. An example method includes receiving an activity profile and a user setting associated with a user. The activity profile is one of multiple predetermined activity profiles selectable by or associated with the user. The method includes applying the activity profile and the user setting to the vehicle to adjust at least one characteristic of the vehicle's cabin to facilitate a performance of an activity during navigation of the vehicle and/or while the vehicle is stationary. The activity profile and the user setting may be received during, prior to, or after receipt of data indicative of the user's identity. Applying of at least the activity profile to the vehicle may be performed upon successful authentication of the user.