Invention Grant
- Patent Title: Nanobody based imaging and targeting of ECM in disease and development
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Application No.: US16258457Application Date: 2019-01-25
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Publication No.: US11597769B2Publication Date: 2023-03-07
- Inventor: Richard O. Hynes , Noor Jailkhani , Hidde L. Ploegh , Yushu Joy Xie
- Applicant: Massachusetts Institute of Technology , Children's Medical Center Corporation , Whitehead Institute for Biomedical Research
- Applicant Address: US MA Cambridge; US MA Boston; US MA Cambridge
- Assignee: Massachusetts Institute of Technology,Children's Medical Center Corporation,Whitehead Institute for Biomedical Research
- Current Assignee: Massachusetts Institute of Technology,Children's Medical Center Corporation,Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge; US MA Boston; US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61P35/04 ; A61K47/68 ; A61K49/08 ; A61K49/00 ; A61K51/10 ; C07K14/78 ; C07K16/18 ; B82Y5/00 ; A61K39/00
Abstract:
Methods for developing disease-related nanobodies and related products and kits are provided. The disease-specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.
Public/Granted literature
- US20190225693A1 NANOBODY BASED IMAGING AND TARGETING OF ECM IN DISEASE AND DEVELOPMENT Public/Granted day:2019-07-25
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