Invention Grant
- Patent Title: Human monoclonal autoantibodies to ADAMTS13 and uses thereof
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Application No.: US15564679Application Date: 2016-04-06
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Publication No.: US11597778B2Publication Date: 2023-03-07
- Inventor: Donald L. Siegel , Stephen Kacir , Eric Ostertag , X. Long Zheng
- Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Applicant Address: US PA Philadelphia
- Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee Address: US PA Philadelphia
- Agency: Saul Ewing LLP
- International Application: PCT/US2016/026224 WO 20160406
- International Announcement: WO2016/164468 WO 20161013
- Main IPC: C07K16/40
- IPC: C07K16/40 ; A61K49/00 ; A61K38/48 ; C12Q1/37 ; G01N33/564 ; A61K39/00
Abstract:
The present invention relates to compositions and methods of use of anti-ADAMTS13 autoantibodies and fragments thereof. In one aspect, the invention includes a composition comprising an isolated anti-ADAMTS13 autoantibody or fragment thereof. In other aspects, methods are described for generating an in vivo model of thrombotic thrombocytopenic purpura (TTP) comprising introducing at least one anti-ADAMTS13 autoantibody or fragment thereof into a model organism and identifying an anti-autoimmune reagent for treating TTP.
Public/Granted literature
- US20190031771A1 HUMAN MONOCLONAL AUTOANTIBODIES TO ADAMTS13 AND USES THEREOF Public/Granted day:2019-01-31
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