Invention Grant
- Patent Title: Methods for generating hematopoietic stem cells
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Application No.: US17828393Application Date: 2022-05-31
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Publication No.: US11597913B2Publication Date: 2023-03-07
- Inventor: Dhvanit I. Shah
- Applicant: The Brigham and Women's Hospital, Inc.
- Applicant Address: US MA Boston
- Assignee: The Brigham and Women's Hospital, Inc.
- Current Assignee: The Brigham and Women's Hospital, Inc.
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: C12N5/0789
- IPC: C12N5/0789 ; A61K35/28
Abstract:
In some aspects and embodiments, the invention provides methods for making hematopoietic stem cells, including for HSCT. The method comprises providing a cell population comprising hemogenic endothelial (HE) or endothelial cells, and increasing activity or expression of DNA (cytosine-5-)-methyltransferase 3 beta (Dnmt3b) and/or GTPase IMAP Family Member 6 (Gimap6) in the HE and/or endothelial cells under conditions sufficient for stimulating formation of HSCs.
Public/Granted literature
- US20220290104A1 METHODS FOR GENERATING HEMATOPOIETIC STEM CELLS Public/Granted day:2022-09-15
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