The present invention provides a leak-proof fluid dispensing system with a pressure sensor and an adjustable dispensing regulator, comprising: a gas cylinder and a pressure dispensing control valve. The dispensing control valve is formed outside the bottle body opening and has an internal channel that communicates with an inlet port, an outlet port, a bottle port, and the joint portion. The internal of the dispensing body includes an inlet valve, an outlet valve, a pressure dispensing regulator, a filter, and a pressure sensor. The pressure at the outlet end of pressure dispensing regulator is lower than or equal to a preset opening pressure value, the fluid is allowed to flow out. With the implementation of the present invention, it may prevent accidental leakage of fluid in the gas cylinder and dynamically monitor the flow gas capacity in the gas cylinder.