By way of example, a data storage system may comprise, a non-transitory storage device storing data blocks in chunks, and a storage logic coupled to the non-transitory storage device that manages storage of data on the storage device. The storage logic is executable to receive a data stream for storage in a non-transitory storage device, the data stream including one or more data blocks, analyze the data stream to determine a domain, retrieve a pre-configured reference set based on the domain, and deduplicate the one or more data blocks of the data stream using the pre-configured reference set.