Systems and methods for simulating cyber-physical systems are disclosed. A plurality of geographic simulation layers representing respective infrastructure sectors of a real-world environment may be generated, and the layers may be linked together with one another to create a multi-layer simulation. The associations between the layers of the simulation may be adjusted, and characteristics of the simulation layers themselves may be adjusted, to ensure that the simulation conforms to characteristics of the real-world environment being simulated. In some embodiments, a multi-user simulation system allows users at separate terminals to execute attack inputs and defense inputs against the simulation to try to destabilize and stabilize the simulation, respectively. Results of the attack inputs and defense inputs may be simultaneously displayed on a plurality of terminals.