Structural design systems, methods, and computer readable media for selective simulation of coverage in a floor plan are disclosed. The system may include a processor configured to: access a floor plan demarcating multiple rooms; perform a machine learning method, semantic analysis, or geometric analysis on the floor plan to identify at least one opening associated with at least one room from the multiple rooms; access a functional requirement associated with the at least one opening; access at least one rule associating the functional requirement with the at least one opening; define at least one area of interest or disinterest using the at least one rule and the functional requirement; access a technical specification associated with the functional requirement; generatively analyze the at least one room, the technical specification and the area of interest or disinterest to define a solution that conforms to the functional requirement; and output the solution.