A system for detection of at least one designated wake-up word for at least one speech-enabled application. The system comprises at least one microphone; and at least one computer hardware processor configured to perform: receiving an acoustic signal generated by the at least one microphone at least in part as a result of receiving an utterance spoken by a speaker; obtaining information indicative of the speaker's identity; interpreting the acoustic signal at least in part by determining, using the information indicative of the speaker's identity and automated speech recognition, whether the utterance spoken by the speaker includes the at least one designated wake-up word; and interacting with the speaker based, at least in part, on results of the interpreting.