A display substrate, a display panel and a display device. A pixel circuit includes a power supply wire providing a power supply voltage to the display pixel; a drive circuit in the non-display region includes a drive signal wire providing a drive signal to the pixel circuit; the power supply wire includes a narrow wire portion overlapping with the drive signal wire and a wide wire portion; a wire width of the narrow wire portion is less than that of the wide wire portion; the display substrate has a first side for display and a second side opposite to the first side, includes a bending region at an edge of the base substrate; the power supply wire and the drive signal wire extend from the first side to the bending region, crossing the bending region to extend to the second side; the narrow wire portion is on the second side.