A multi-chip integrated circuit and an interactive communication method for the multi-chip integrated circuit are provided. The multi-chip integrated circuit includes multiple low-voltage chips connected in series with each other instead of an ultra-high voltage chip, to reduce requirements on technology for the chip. In addition, the multiple chips communicate with each other through internal communication ports based on a differential signal, to enhance reliability of communication. Two adjacent chips are connected in series and a low-voltage power supply is arranged, so that a voltage difference between communication ports of the two adjacent chips is small.