An information handling system (IHS) includes a sensor for sensing a physical configuration of the IHS, the physical configuration dependent upon a position of a hinge of a housing of the IIS. A first proximity sensor probe may sense whether a first biological entity element is proximate to a first antenna of the IHS, and a second proximity sensor probe may sense whether a second biological entity element is proximate to a second antenna of the IHS. The IHS may reconfigure use of at least one of the first antenna and the second antenna in response to the sensing of at least one of the first proximity sensor probe and the second proximity sensor probe.