A method of operating a user equipment comprises addressing multi-subcarrier system resources using multiple different numerologies available within a single carrier, the multiple different numerologies comprising a first numerology having resource blocks (RBs) with a first bandwidth and a first subcarrier spacing, Δf1, and a second numerology having RBs with a second bandwidth and a second subcarrier spacing, Δf2, which is different from Δf1, wherein the first numerology is aligned in the frequency domain relative to a frequency reference, Fref, according to m*Δf1+Fref and the second numerology is aligned in the frequency domain relative to the frequency reference, Fref, according to n*Δf2+Fref, where m and n are integers. The method further comprises transmitting and/or receiving information within the single carrier according to the at least one of the multiple different numerologies.