Systems and methods for orchestration and configuration of end-to-end network slices across a 3GPP core network and ORAN are described. The network includes a NSMF that receives an AllocateNSI operation with attributes to allocate an NSI. The AllocateNSI operation includes an attributeListIn parameter that specifies network slice properties in a ServiceProfile to be supported by the NSI. The NSMF determines that a new NSI is to be created rather than using an existing NSI and that the new NSI is to contain a NSSI (RAN) and a NSSI (CN). The NSMF communicates with a NSSMF (RAN) and NSSMF (CN) to create the new NSI. The new NSI includes an O-CU-CP, O-CU-UP and O-DU VNFs, and an O-RU PNF for the NSSI (RAN), and UPF, AMF, and SMF VNFs for the NSSI (CN).