A control and protection circuit of a heater, a towel heating barrel and a control method thereof are provided in this disclosure. The control and protection circuit of the heater includes a power module, a power supply module, a control module, a temperature detection module and a heating module. The power module, the power supply module and the heating module are connected in series to supply power to the heating module, the control module is in signal connection with the power supply module to control on and off of the power supply module, and the temperature detection module in signal connection with the control module. The power supply module includes a high-temperature protection switch, a fuse and a relay. The control and protection circuit of the whole heater has three levels of protection, which can not only effectively provide high-temperature protection, but also ensure service life of the heater.