The present disclosure provides various embodiments of systems and related methods to track and cryptographically verify system configuration changes. More specifically, systems and methods are disclosed herein to track an original system configuration of an information handling system (IHS) as the system was built by a manufacturing facility, and any system configuration changes that are made to the original system configuration after the IHS leaves the manufacturing facility. Once a user takes ownership of the IHS, systems and methods disclosed herein may be used to cryptographically verify a current system configuration of the IHS. In doing so, the present disclosure provides a way to authenticate or validate system configuration changes that may occur after the IHS leaves the manufacturing facility.