Machine learning is utilized to learn an optimized quantization configuration for an artificial neural network (ANN). For example, an ANN can be utilized to learn an optimal bit width for quantizing weights for layers of the ANN. The ANN can also be utilized to learn an optimal bit width for quantizing activation values for the layers of the ANN. Once the bit widths have been learned, they can be utilized at inference time to improve the performance of the ANN by quantizing the weights and activation values of the layers of the ANN.