A method of depth-of-field simulation, including receiving a plurality of images, predicting a layer of interest mask of the plurality of images, determining a plurality of mean brightness anchor values of a respective plurality of layers of interest window arrays, setting a plurality of layers of interest set of binary codes, determining a hamming distance between plurality of layers of interest set of binary codes, determining a cost volume based on the hamming distance, resampling a vertical cost based on a vertical ordinal direction the cost volume, resampling a horizontal cost based on a horizontal ordinal direction the cost volume, determining an all-in-focus layer based on the vertical cost and the horizontal cost, determining an out-of-focus layer based on the vertical cost and the horizontal cost and determining a depth of the all-in-focus layer and out-of-focus layer.