The subject matter discussed herein relates to systems and methods for generating a clinical outcome based on creating a task-specific model associated with processing raw image(s). In one such example, input raw data is acquired using an imaging system, a selection input corresponding to a clinical task is received, and a task-specific model corresponding to the clinical task is retrieved. Using the task-specific model, the raw data is mapped onto an application specific manifold. Based on the mapping of the raw data onto the application specific manifold the clinical outcome is generated, and subsequently providing the clinical outcome for review.